We are looking for a highly motivated Postdoc with strong interest in epigenetic regulatory mechanisms in development and disease.
During development a large number of widely differing and specialized cell types are generated from a single totipotent zygote. Tissue specific transcription factors work in concert with epigenetic modifiers to establish cellular identity during developmental decisions and epigenetic regulatory mechanisms contribute to the maintenance of distinct chromatin states and cell-type specific gene expression patterns.
The aim of the project is to determine the dynamic epigenetic events occurring during cell commitment, lineage specification, differentiation and dedifferentiation in normal development and pathological alterations of the heart and identify key drivers of these processes. Particular emphasis here will be placed on the role of cell-cell communication and signalling in epigenetic programming of the cardiovascular system. Clarifying the mechanisms regulating the balance and transition between dynamic and stable epigenetic states is fundamental to understanding heart development and function and might uncover novel therapeutic strategies for heart disease.
We use a wide range of biochemical, molecular/cell biological, embryological and transgenic techniques to study the transcriptional and epigenetic networks in development and disease both in cell culture and in vivo in mouse and zebrafish.
The applicant should possess a solid background in molecular and cell biology; specific experience in embryonic development, stem cell biology and/or epigenetics will be an advantage.
The successful candidate will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.
To apply, please send an application letter, CV and contact information of at least two referees to Prof. Dr. Gergana Dobreva (Gergana.Dobreva@mpi-bn.mpg.de).
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 2015, 17(3):287-99
Cheedipudi S, Genolet O, Dobreva G. Epigenetic inheritance of cell fates during embryonic development. Front Genet 2014, 5:19.
Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S. Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ Res 2013, 113(7):856-62
Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G. The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell 2012, 23(1):58-70