Metabolic reprogramming and alterations in nuclear architecture are hallmarks of cancer cells. Mounting evidence indicates that tumour metabolism is intricately interconnected with epigenetic reprogramming and nuclear reorganization in cancer cells. In a screen, we identified factors that play a fundamental role in lung cancer development and progression and in regulating lung cancer cell metabolism. The objective of the proposed research project is to elucidate on the one hand the mechanisms by which these factors regulate cancer cell metabolism and on the other hand how changes of cell metabolism affect chromatin association with the nuclear lamina, genome architecture and the epigenetic landscape. We expect that this work will contribute to better understanding the molecular players at the interface of cancer metabolism and epigenetics and may provide clues to novel approaches for tumour treatment.
We use a wide range of biochemical, molecular/cell biological and transgenic techniques to study the crosstalk between epigenetics and metabolism both in cell culture and in vivo in mice.
The applicant should possess a solid background in molecular and cell biology; specific experience in epigenetics and/ or studying cell metabolism will be an advantage.
The successful candidates will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.
Prof. Dr. Gergana Dobreva
Gergana.Dobreva@medma.uni-heid
University of Heidelberg
Mannheim
