SE BUSCA: Doctor/a interesado/a en solicitar una ayuda Juan de la Cierva (Formación o Incorporación) en la convocatoria 2017 para investigar dentro del grupo “Retrotranscriptasa del virus de la inmunodeficiencia humana y terapia antirretroviral” del Centro de Biología Molecular Severo Ochoa ( www.cbm.csic.es ). SE OFRECE: Nuestro laboratorio está muy interesado en conocer los mecanismos moleculares implicados en la replicación de retrovirus, en particular del virus de la inmunodeficiencia humana (VIH). Estamos interesados en desarrollar variantes de la retrotranscriptasa (RT) viral de interés biotecnológico, entender los procesos de recombinación y desplazamiento de banda mediados por la RT, y contribuir al diseño de nuevos fármacos que inhiban su actividad ribonucleasa H, además de otras dianas terapéuticas aún no explotadas para el tratamiento antirretroviral. REQUISITOS DEL CANDIDATO/A: - Cumplir los requisitos establecidos en la convocatoria ( http://www.boe.es/diario_boe/txt.php?i...
Two 2-3 year postdoc contracts are available at the laboratory of Rafael Sanjuán (University of Valencia, Spain). Starting date: flexible (mid 2017 to early 2018). Place: recently created Institute for Integrative Systems Biology (I2SysBio), Valencia, Spain. Project title: Collective Infectious Units and the Social Evolution of Viruses. Funding: ERC Consolidator Grant, 2017-2022. Goal: understand how multi-virion infectious units determine social-like interactions in viruses (cooperation versus conflict). We will use vesicular stomatitis virus and/or enteroviruses and/or baculoviruses as model systems. Candidates should have a background in virology and molecular/cell biology. ERC project summary: A widely accepted view in virology is that virions function as independent infectious units. However, recent work by us and others indicates that viruses are often transmitted as more complex structures, such as virion aggregates, lipid vesicles or protein matrices harb...
Se busca candidato/a para solicitar un Contrato de Formación de Profesorado Universitario (FPU) del Ministerio de Educación, Cultura y Deporte, en la convocatoria 2016 y desarrollar un proyecto de Tesis doctoral en el Grupo de Retrotranscriptasas y Terapia Antirretroviral (IP Luis Menéndez Arias) en el Departamento de Virología y Microbiología del Centro de Biología Molecular Severo Ochoa (CSIC-UAM), participando en el Proyecto “Diseño de nuevas retrotranscriptasas del virus de la inmunodeficiencia humana, útiles en aplicaciones biotecnológicas”. En nuestro laboratorio, estamos interesados en el estudio de dianas terapéuticas en el VIH, con un enfásis particular en su retrotranscriptasa (RT) (o transcriptasa inversa). Esta enzima es la responsable de la replicación del ARN que constituye el material genético del virus. Tradicionalmente, nuestros esfuerzos se han dirigido hacia la consecución de dos objetivos importantes: (1) entender el papel que juegan distintos aminoácidos en la es...
¿Te interesa saber cómo los bacteriófagos reconocen y matan a las bacterias? El grupo del Dr. Mark van Raaij lo estudia a nivel molecular, resolviendo las estructuras cristalográficas de las proteínas implicadas. También hacen mutantes de las proteínas y los fagos para intentar cambiar su selectividad. Cada vez hay más bacterias patógenas resistentes a los antibióticos , motivo por el cual ha aumentado mucho el interés por encontrar otros métodos que permiten reconocer dichas bacterias y combatirlas. Una opción consiste en usar bacteriófagos y proteínas derivadas de éstos, ya que sus fibras permiten reconocer determinadas bacterias, sus tailspikes también sirven para debilitarlas y las endolisinas son capaces de matar a bacterias gram-positivas. Los candidatos interesados con nota media alta (preferiblemente > 8.5) en Biología, Bioquímica, Biotecnología o similar pueden contactar con: Mark van Raaij, CNB-CSIC, Madrid; http://www.cnb.csic.es/~mjvanraaij E-mail: mjvan...
At the Institute for Virology of the University of Duisburg-Essen (Campus Essen) one postdoctoral position is available. We are seeking for candidates with a Ph.D. in virology or immunology and with fundamental interest in biomedicine. Experience in flow cytometry and mouse experiments is required for the position. Start of the project should be in August/September 2015. Our work is focussed on the interaction of retroviruses with cells of the immune system. The goal is to develop new therapeutic approaches and vaccines against retroviral infections. The experimental model is the infection of mice with the Friend murine leukemia virus. The main focus of the project will be on the function of CD4+ regulatory T cells during retroviral infections. An overview can be found in: Front. Biosci. 12: 1544-1551 (2007) and especially Retrovirology 8: 76 (2011). The salary is commensurate with TVL E13 and the appointment is for 2 years with possible extension. The interviews with short listed...
The Department of Infectious Diseases / Molecular Virology of the University Hospital Heidelberg 1 PhD / Doctoral Student Within the new research project “Visualisation of Hepatitis B Virus entry and spread” of the SFB 1129 „Integrative Analysis of Pathogen – Replication and Spread“ we are looking for One PhD student
The Institute of Molecular Virology (Director: Prof. Dr. Frank Kirchhoff) is seeking a postdoctoral fellow and a PhD student to participate in research focusing on the pathogenesis of AIDS. The positions will be funded by the German Research Foundation (DFG) and an ERC advanced grant. The candidates will investigate cellular factors that are involved in viral immune sensing and the host defense against HIV as well as their viral antagonists. Their work will help to define the mechanisms underlying the high levels of immune activation in HIV-infected individuals that drive progression to AIDS and may lead to new strategies to prevent these damaging effects. Ideal candidates will be excited to do fascinating science together with a team of highly cooperative and competent lab members. They will be creative, curious, highly motivated, and have a strong background in cell biology, immunology or virology. Applicants can read, write and speak English fluently, are familiar with Microsoft of...
The Institute of Medical Virology at the University Hospital Frankfurt, Germany, offers 2 postdoctoral positions for two years (extension possible) starting December 2013 in the laboratory of Prof. Dr. Oliver Keppler. Replication of major human pathogens such as Human Immunodeficiency Virus (HIV) can be potently suppressed by intrinsic immunity factors, also referred to as restriction factors. In turn, HIV has evolved gene products that allow circumvention of these antiviral responses. One focus of the laboratory is to identify and study new restriction factors and decipher mechanism of viral counteraction. We have a strong track record in this field (Goffinet et al., Cell Host & Microbe (2009); Erikson et al., PNAS (2011); Baldauf et al., Nature Medicine (2012)) and are particularly interested in factors that may modulate the efficiency of HIV transmission. The successful candidate will have a strong publication record and practical experience in molecular biology, biochem...
