Oferta compartida por Cristina
(Epigenetics)
Job Advert
We have an exciting opportunity for a motivated and collaborative scientist working at the interface of
metabolism and epigenetics. This project will investigate novel metabolic factors driving diabetic
cardiomyopathy, and test targeted dietary interventions for therapeutic efficacy. This post forms one
half of a collaborative project between the Trefely lab at Babraham Institute (BI), and the Swietach and
Heather labs at Oxford University. The BI based post holder will lead metabolomic and epigenomic
analyses on mouse tissue samples provided by the Oxford-based researcher and pursue mechanistic
experiments in cultured human induced pluripotent stem cell (iPSC) derived cardiomyocytes. The
animal models of disease, cardiac measurements, and tissue collection will be the remit of the already
required Oxford-based researcher, but training and exchange of knowledge with the BI-based scientist
will be encouraged. The project will advance our understanding of the metabolic-epigenetic interface
in diabetic cardiomyopathy, using novel insights provided by a genetic mouse model of an inborn error
in metabolism - propionyl CoA carboxylase deficiency. This post offers an opportunity for a talented
scientist to hone expertise in metabolomics and epigenomics whilst extending their scope and impact
across disciplines through collaboration. Although the work programme is on cardiac tissue, prior
experience in cardiovascular research is not essential and we welcome scientifically diverse candidates
keen on expanding their research portfolio.
The Trefely lab is focussed on the links between diet-derived metabolites and epigenetic regulation.
We study how compartmentalisation of metabolic pathways affects the supply of metabolites within
the nucleus and their functions in epigenetic modifications. This project will synergize cutting-edge
liquid chromatography-mass spectrometry (LC-MS) based methods for metabolomic analysis including
subcellular analyses developed in the Trefely lab with state-of-the-art techniques for iPSC-derived
cardiomyocyte culture (supported by the Heather lab) and epigenomics profiling. The candidate will
take advantage of ready access to top tier facilities and resources available at the Babraham Institute.
The ideal candidate must have a PhD in cell biology, molecular biology, biochemistry or similar field,
with experience in analysis of complex data sets such as metabolomic, sequencing or proteomics.
Collaboration is an essential part of the project and the candidate must demonstrate strong
communication skills, and be adaptable to work flexibly and independently to develop the project. The
candidate will be trained in specialised metabolic analyses employing liquid chromatography-high
resolution mass spectrometry (LC-HRMS) in the Trefely lab but prior experience in metabolomic
analysis is an advantage. Experience in stem cell culture and metabolic research is highly desirable for
this post since a considerable part of this project will involve the development of iPSC culture models
with metabolic perturbations. The role will require independent problem solving, critical thinking,
creativity, and an eye for detail.
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The successful candidate will work in, and contribute to, a friendly, inclusive, collaborative and
respectful working environment, where they lead their project’s development with enthusiasm, and
actively contribute to a programme of group meetings and departmental seminars at BI as well as
maintaining regular contact with collaborators at Oxford.
This is a limited term appointment with funding for this post expected to be available for a period of 3
years.
Informal inquiries should be made to Sophie Trefely (Sophie.Trefely@babraham.ac.uk).
For more information on the work of the groups, please visit:
https://www.babraham.ac.uk/our-research/epigenetics/sophie-trefely
https://www.dpag.ox.ac.uk/team/pawel-swietach
https://www.dpag.ox.ac.uk/research/heather-group
Applicants must hold a PhD or have their thesis submitted when commencing the post. Please note
that you will be appointed on the starting salary of £34,500 per annum, if you have not yet been
awarded your PhD. All newly appointed postdocs will commence on the salary/scale point that reflects
the number of years' post-PhD experience they hold on 30th June in the calendar year they commence
employment. Due to the available funding for this grant the role will better suit a Postdoc with up to 4
years’ post-PhD experience.
Closing date for applications is Sunday, 19 January 2025.
However, we reserve the right to close the vacancy early depending on the volume of applications
received.
The Babraham Institute welcomes applications from all sections of society.
NO AGENCIES PLEASE
The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and
developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions
and attracts highly motivated and talented people. The Babraham Institute abides by the principles of
the government’s Disability Confident Scheme and has a positive approach to employing disabled
people.
Department
Epigenetics
Contract type
Fixed Term Contract
Hours
37
Salary
Starting salary is £37,364 per annum to £40,828 per annum (depending on number of years post-PhD
experience)
